Enzymes are substances naturally present in all living organisms. They trigger or speed up thousands of chemical reactions in the body. For example, respiration, digestion, immune function, metabolism and growth. They work at the cell, tissue and organ level. Serrapeptase and Nattokinase are powerful enzymes which are used as systemic enzyme supplements. Systemic enzyme therapy has been used safely for more than 50 years by natural and alternative practitioners as a natural and effective way to support healthy levels of inflammation, help against infection, help in recovery after surgery and remove excess fibrin build-up in your organs and blood.

Research shows serrapeptase possesses significant anti-inflammatory, proteolytic (protein dissolving) and fibrinolytic (fibrin dissolving) properties. It reduces scar tissue, improves tissue healing and supports a healthy respiratory system.   Nattokinase has powerful anti-inflammatory and fibrin-degrading activity. It prevents and dissolves blood clots, promotes healthy circulation, and supports normal blood pressure. It also helps maintain healthy C-reactive protein levels (CRP). CRP is an inflammation marker and a serious risk factor for heart disease.

SerrapeptaseNattokinase
History of UseSerrapeptase is a protease that has been used in Japan and Europe for over four decades for its anti-inflammatory activity.Natto has been known for centuries for its positive medicinal properties, particularly for cardiovascular disorders. A researcher, Hiroyuki Sumi, identified the active enzyme in natto and showed its ability to dissolve blood clots.
Where do they come from?Serrapeptase was originally derived from a species of bacteria called Serratia mercesans, which is found in the intestine of silkworms. The bacteria produces an enzyme that enables the silkworm to dissolve its silken cocoon and emerge. Serratia is now grown in cultures and fermented to produce serrapeptase. Nattokinase is derived from natto, a traditional Japanese food made from fermented soybeans. To make nattō, soybeans are fermented with the beneficial bacteria Bacillus natto. During fermentation, the Bacilli produce protease enzymes, the most important of which is nattokinase.
What do they do?Both serrapeptase and nattokinase are widely known for helping the immune system respond to chronic or acute injury. These systemic enzymes act on protein-based complexes such as fibrin in scars around damaged tissue. Fibrin performs an important function in the body, including clotting and wound healing. However, excessive fibrin build-up in the body can impair normal blood flow which may lead to increased blood viscosity, swelling, edema, pain, inflammation and more serious cardiovascular problems. People with pulmonary fibrosis experience low oxygen levels in the blood and breathlessness due to excessive fibrin build-up in the lungs. This extra fibrin thickens and stiffens the lungs and blocks healthy oxygen and carbon dioxide exchange. This is why supplementing serrapeptase and nattokinase can help your body to relieve symptoms caused by too much fibrin build-up.
Research shows serrapeptase possesses significant anti-inflammatory, proteolytic (protein dissolving) and fibrinolytic (fibrin dissolving) properties. It reduces scar tissue, improves tissue healing and supports a healthy respiratory system. Nattokinase has powerful anti-inflammatory and fibrin-degrading activity. It prevents and dissolves blood clots, promotes healthy circulation, and supports normal blood pressure. It also helps maintain healthy C-reactive protein levels (CRP). CRP is an inflammation marker and a serious risk factor for heart disease.

Will Serrapeptase and Nattokinase cure your Pulmonary Fibrosis?

While the fibrinolytic activity of these systemic enzymes can help with scar tissue build-up and inflammation reduction, they cannot be considered cures for the disease. Mechanisms which cause uncontrolled scarring may remain in place despite the use of systemic enzymes. However, while conventional medicine has yet to find a solution to address pulmonary fibrosis (PF), systemic enzyme therapy provides hope.

What you can do to help in the fight against Pulmonary Fibrosis

We have a lot of anecdotal evidence showing the benefits of systemic enzyme supplements on symptoms associated with PF. People who take systemic enzyme supplements regularly, have noticed improvements – they say they cough less and are able to do more without feeling breathless. However, there is a lack of evidence from well-designed controlled studies showing the role of enzyme supplements in health promotion and PF treatment. At Pulmonary Fibrosis Now!, we are conducting research to study the effects of systemic enzymes on symptoms and other quality of life parameters in PF patients. We would like to invite people diagnosed with pulmonary fibrosis to participate in this important research that may help you or other people suffering from PF.

97 comments
  • Victoria
    Posted on October 30, 2019 at 2:52 pm

    Hello, I’ve been living with PF for 22 years
    I have been continuously searching for alternative treatments.
    Had serrapeptase years back .
    I will like to give it another trial .

    Reply
    • Neha
      Posted on November 8, 2019 at 4:24 pm

      Hello Victoria, I have messaged you details of our research study and some forms you need to complete. Please review and complete the forms so we can determine if you are eligible to participate in this study. Thank you very much

      Reply
    • Georgi
      Posted on April 23, 2020 at 7:43 am

      Hello, I have three pelvic surgeries, two varicocelectomies and one hernia when I was a baby. After the last varicocelectomy I started having pain and discomfort in my testicle and a few other symptoms that are similar to chronic pelvic pain syndrome. I think after so many surgeries on one place I have developed significant scar tissue and I have an awful range of motion. I started taking Serrapeptase a month ago and it made wonders for me I almost had my previous life back, till I had a huge flare up a few days ago. Whatt would you suggest doing now? I started taking two times two capsules 120,000 SPU with the idea I am overweighted 100 kilograms and maybe my scars there need more to be dissolve. Thank you for all that you are doing!

      Reply
      • PF NOW
        Posted on April 28, 2020 at 6:06 pm

        Hello Georgi, I would recommend increasing your dose to 6 capsules a day, so you can take 3 capsules twice a day or 2 capsules 3 times a day of the serrapeptase while you are having the flare up. You can go down to the 4 capsules a day once your flare up subsides. Alternatively, you can add Serracor-NK to your regimen and take 1 capsule of the Serracor-NK twice a day in addition to the 2 capsules of Serrapeptase twice a day that you are currently taking. Hope this helps and hope you feel better soon. Please let us know if you need any other information and would love to hear back from you about how the increased dosage is working for you.

        Reply
      • Doug
        Posted on June 20, 2020 at 2:27 pm

        Take NAC (N-acetyl cysteine) Milk Thistle and good old Vitamin C to avoid flareups! I’ve had RA for approx. 4 years now. I don’t take any RA drugs. I take the above 2 – 3 times daily. NO Flareups!

        Reply
      • Cathy McMahan
        Posted on September 15, 2020 at 2:51 pm

        you do realize they use metal clips. And many have pain from them.

        Reply
  • Aesop Lianos
    Posted on November 1, 2019 at 6:01 pm

    I intend to try serrapeptase and would be happy to take part in your research. I have recently been diagnosed with pulmonary fibrosis

    Reply
    • PF NOW
      Posted on November 15, 2019 at 5:22 pm

      Hi Aesop, we are very excited that you have enrolled to participate in our enzyme study!

      Reply
      • Patrick Hayes
        Posted on January 6, 2020 at 11:23 pm

        I was diagnosed with IPF about one year ago and since then I’ve noticed an increase in symptoms including breathing difficulties and coughing. I’m becoming more dependent on oxygen. I did try OFEV for about 6 months and my pulmonologist discontinued it because of horrible side effects and severe weight loss. I read the IPF now articles in enzyme use and your research and found them to be hopeful. I did fill out a questionnaire to be in the study and I hope to hear from you soon to find out if I qualify.

        Reply
  • ASIF
    Posted on November 8, 2019 at 6:58 am

    Is it necessary to use both serrapeptase and nattokinase or any one one can be taken?

    Reply
    • Neha
      Posted on November 8, 2019 at 4:19 pm

      The enzymes serrapeptase and nattokinase can be taken on their own but when taken together, they do have powerful synergistic effects. So our recommendation is to use both

      Reply
  • Morgan Beatty
    Posted on November 12, 2019 at 9:20 pm

    I’ve recently been diagnosed with IPF and would like information about participating in one of your studies

    Reply
    • Neha
      Posted on November 12, 2019 at 11:49 pm

      Hi Morgan, thank you for your interest in participating in our study. Our current study is examining the effects of systemic enzyme supplements on symptoms and quality of life in people with pulmonary fibrosis. As part of the study, we are giving away a free three month supply of enzyme supplements to people with pulmonary fibrosis who qualify. This is the link to some information about the enzyme study : https://pulmonaryfibrosisnow.org/survey/ You can copy and paste the link in your browser. You can call us at 951-249-3054 or email us with any questions.

      Reply
  • Wendy
    Posted on November 14, 2019 at 8:32 am

    Hallo Im visiting the pulmonary specialist with my mum next monday. Ive suggested these steps to her plus bone broth and bee pollen ( 82 years) but she listens to the Dr,s and although they help her medication seriously needs reviewed considering her weight. I decided 5 mins ago to get the specialist on my side if he would suggest taking nattokinase and serrapeptase she might listen. She could be talked into helping research Im sure of that.Could she possibly take part in your research?

    Reply
    • PF NOW
      Posted on November 15, 2019 at 5:12 pm

      Hi Wendy, I’m sending you some details and documents via email for you to review. Once I get a little more information from you, I can let you know if she qualifies for the study. Her age is certainly not a barrier. Thank you for reaching out to us!

      Reply
  • myphysicalwellbeing
    Posted on November 15, 2019 at 9:47 pm

    hi thanks for the information

    Reply
    • PF NOW
      Posted on December 13, 2019 at 5:21 am

      You are welcome!

      Reply
  • Digsbee
    Posted on November 19, 2019 at 11:50 am

    Does this have to be a heart issue for the study? What if a person had surgery on their colon for cancer And it never healed right leaving scarring and lots of pain? Can they do your trial please? Is it for Serrapeptase and Nattokinase?
    Thank you

    Reply
  • Digsbee
    Posted on November 19, 2019 at 11:51 am

    Does this have to be a heart issue for the study? What if a person had surgery on their colon for cancer And it never healed right leaving scarring and lots of pain? Can they do your trial please? Is it for Serrapeptase and Nattokinase?
    Thank you

    Reply
    • PF NOW
      Posted on November 19, 2019 at 4:35 pm

      Hi, I’m sorry for all the pain you are going through. Our research study is specifically for lung fibrosis and the symptoms associated with it. However, Serrapeptase and Nattokinase have been shown to help with pain, swelling, inflammation and wound healing so if you’d like, you can try taking the supplements and see if they help. Please let us know if you need any more information.

      Reply
  • Tal
    Posted on November 30, 2019 at 10:43 pm

    Hi.what brand do you use for your research.
    I need a recommendation for a good brand to treat uterine fibroids.

    Reply
    • PF NOW
      Posted on January 31, 2020 at 6:53 pm

      In our current research study, we are using Serracor-NK from AST enzymes and Serra Rx from Biomedic Labs

      Reply
  • Joe D
    Posted on December 3, 2019 at 3:36 am

    I’d like to participate in the study. My last doctor’s visit, my doctor said I had an abnormal EKG and advised to get further testing.

    Reply
    • PF NOW
      Posted on December 27, 2019 at 5:39 pm

      Hello Joe, How are you doing? Have you got back your test results? Please write to us on fight@pulmonaryfibrosisnow.org or call us on 951-249-3054 and we can discuss details about the study and your participation.

      Reply
  • Andre Z
    Posted on December 12, 2019 at 11:03 pm

    Hi ,
    I have just came across your article . Is it still open for new participants with PF, for your research?
    Thanks,

    Reply
    • PF NOW
      Posted on December 13, 2019 at 12:51 am

      Hi Andre, Yes, we are still enrolling participants in this research study. I will email you some information about the study and then we can set up a time to have a phone call so I can explain it to you an answer any questions you may have.

      Reply
  • Steven Lander
    Posted on December 13, 2019 at 9:56 am

    Hi, I was interested in using serapeptase but I do have some scar tissue on my heart which my cardiologist said was minimal at the time. My Dr says that serapeptase would cause my heart to fall apart because the scar tissue is holding it together. Does that sound right? I was really wanting to try it due to the fact that I am suffering from an acute condition of peyonie’s disease but now feel let down because of what my Dr has said.. cheers, Steve

    Reply
    • PF NOW
      Posted on December 27, 2019 at 6:54 pm

      Hi Steve, there are differing views on the use of Serrapeptase in people with scar tissue on the heart. Some people/doctors say it is okay to continue taking it and other people are skeptical about continuing supplementation. Since Serrapeptase dissolves scar tissue in the body, it is logical that it would not “spare” the vital scar tissue on your heart. The use of proteolytic enzymes including serrapeptase has been widely discussed in people who have undergone cardiac ablation. This is a procedure which creates small scars on your heart tissue to treat irregular heartbeats. There does not seem to be any definitive answer to this question

      Reply
      • steven lander
        Posted on January 11, 2020 at 2:54 am

        i have just been reading about German dr Hans Nieper who first discovered its use on heart scar tissue and cleaning plaque build up in arteries. i looked him up on Wickapedia and he was the real deal. my heart muscle has lost a small part of movement which would be from the scar tissue. i am always looking at ways to heal myself and would really like to believe that it could disolve the scar tissue. i found this information on a site that is promoting the sale of the serapeptase supplement which includes Dr Hans Nieper words on it. i would really appreciate it if you could have a look and tell me what you think. personaly i think there would be a lot of people with hearts falling apart if it was the case although i know Dr Google isnt always right but could they make such a claim to sell their product if it was to cause your heart to fall apart? the web site is ww. transformyourheart.com. i am looking forward to your reply. Cheers, Steve

        Reply
  • Mary
    Posted on December 25, 2019 at 8:16 pm

    Have been diagnosed with IPF and would like to start on the systemic enzymes but not sure where or how. Live in australia.

    Reply
    • PF NOW
      Posted on December 27, 2019 at 4:37 pm

      Hi Mary, thank you for reaching out to us. We are able to send the enzymes to Australia. Please look out for an email from fight@pulmonaryfibrosisnow.org with more details.

      Reply
  • Mandy Donaldson
    Posted on December 28, 2019 at 7:38 pm

    Hi there
    I’m in New Zealand. Can I be part of your research study. I have been diagnosed with interstitial lung disease possibly caused by a collagen vascular disease or ibs. Thanks cheers Mandy.

    Reply
    • PF NOW
      Posted on January 31, 2020 at 6:57 pm

      Hi Mandy, I have emailed you some details about our research study. Looking forward to your response. Thank you for reaching out to us and for your interest in participating in our study.

      Reply
  • Patrick Hayes
    Posted on January 7, 2020 at 3:26 pm

    I’ve was diagnosed with IPF about 15 months ago. I’ve tried OFEV but my pulmonologist discontinued it because of severe weight loss and other side effects. I am very interested in being apart of your enzyme study. I did fill out a demographic form relating to the study but haven’t heard back. I live in Massachusetts.
    Thank you

    Reply
    • PF NOW
      Posted on January 7, 2020 at 4:18 pm

      Please look out for an email from us with some study details

      Reply
  • Dave
    Posted on January 10, 2020 at 11:03 am

    Hi there, I am based in Singapore and would like to have info on the trial for a loved one.

    Reply
    • PF NOW
      Posted on January 10, 2020 at 4:48 pm

      Please look for an email from us with some study details

      Reply
  • Kim BANFORD
    Posted on January 12, 2020 at 11:36 pm

    Hello we are in Canada & would like to have the products for my husband. He was just diagnosed in late Oct & by CT scan & just had a bronchoscope. He is 70 & has experienced pneumonia in the last 6 months. He coughs all the time & is at around 60% lung capacity very short of breath with little activity . We are just waiting to get home oxygen. He also suffers from acid reflux & hiatus hernia he is on a PPI. Would love to be in your study but if we can’t how can we get the supplements? Please help this is such a horrible diagnosis this IPF.

    Reply
    • PF NOW
      Posted on January 16, 2020 at 2:23 pm

      Hello Kim, so sorry to hear about your husband’s diagnosis. We are able to send the supplements to Canada so if your husband qualifies, he can participate in our study. Please look out for an email from us with some study details and feel free to reach out with any questions

      Reply
  • Tell
    Posted on January 19, 2020 at 7:28 am

    I’m interested in your study. I have chronic Pulmonary Sarcoidosis. I have taken Serrapeptase. I have just heard of Nattokinase.

    Reply
    • Tell
      Posted on January 23, 2020 at 10:55 pm

      I didn’t get a response, so I’m reaching out again to see if I would be able to participate in the study? I have Sarcoidosis but I have scarring in the lungs.

      Reply
      • PF NOW
        Posted on January 31, 2020 at 5:40 pm

        Hello, we have sent you an email with some study details and contact information. Thank you for your interest in our research study!

        Reply
    • PF NOW
      Posted on January 31, 2020 at 5:36 pm

      Please look out for an email from us giving you study information. You can call me to further discuss your participation in the study. Thank you for reaching out to us.

      Reply
  • Stephen Gould
    Posted on January 21, 2020 at 3:59 pm

    Hi, just found this site – IPF for 2 years, started on serrapeptase and would also like to participate in teh study. Haven’t started nattokinase yet.

    Reply
    • PF NOW
      Posted on January 21, 2020 at 4:55 pm

      Hello Stephen, how long have you been on serrapeptase? Are you still taking it? Please look our for an email from us with some study details.

      Reply
  • Herta Ch. Razaq
    Posted on January 23, 2020 at 4:40 pm

    My sister-in-law (73 years old) was diagnosed with COPD ca. Two years ago. She is not getting better despite of seeing her doctor regularly. Would she qualify to take part in this study? She lives in Germany.
    Kind regards,
    HertaCh. Razaq

    Reply
    • PF NOW
      Posted on January 31, 2020 at 7:01 pm

      Hello Herta, I am sending you an email with some study details. Please have your sister-in-law review it to see if our research study is something she would be interested in participating. We can then set up a time to talk about more details. Thank you for reaching out to us!

      Reply
  • Sasha
    Posted on February 2, 2020 at 4:06 pm

    Hello,
    Have you conducted studies or have any information on Nattokinase and or Serrapeptase impact on Dupuytren’s Contracture? I have read that these enzymes can help to minimize the effects of the disease. Thank you

    Reply
    • PF NOW
      Posted on February 3, 2020 at 6:26 am

      Hello Sasha, we have not conducted any studies on Dupuytren’s contracture. However, Serrapeptase and Nattokinase are proteases with fibrinolytic effects so they are likely to help with any condition that has scar tissue buildup. Hope this helps.

      Reply
  • Donna Roper
    Posted on February 9, 2020 at 10:24 am

    Hi I’ve just been diagnosed with PF and have started taking serrapeptase but not sure how much to take and also had never heard of Nattokinase and would be interested in being part of the study. I’m 54 and very lucky to have little symptoms at the moment. If you don’t feel I’d been suitable please could you give me some advice about what I should take so I could do it myself. Many thanks 😊

    Reply
    • PF NOW
      Posted on February 11, 2020 at 5:27 am

      Hi Donna, thank you for reaching out to us. I need a little more information from you to see if you qualify for the research study. Please look out for an email from us.

      Reply
  • Linda
    Posted on March 4, 2020 at 4:16 pm

    I’ve recently been diagnosed with Sarcoidosis. Old scarring on lungs and lymph’s as well. Would I be a candidate for your study? Would Serrapeptase help me? I’ve been coughing since 2017, have had 2 Bronchoscopies and recent Mediastinoscopy. Looking for help other than what doctors are prescribing which is Predisone.

    Reply
    • PF NOW
      Posted on March 6, 2020 at 6:30 pm

      Hi Linda, Please look out for an email from us with some study information

      Reply
  • Derek
    Posted on March 9, 2020 at 7:01 am

    I had a blood clot right lung turned into a scar I’m in so much pain when I stop my blood thinners do you think this could clear my old blood clot ? It’s been 2 years now

    Reply
    • PF NOW
      Posted on March 10, 2020 at 4:16 pm

      Hi Derek, sorry to hear about the pain you are going through. Serrapeptase and Nattokinase have been shown to have anti fibrotic effects and possibly clear blood clots. However, it is not recommended to take Nattokinase while you are on blood thinners as it can increase your risk for bleeding. Please consult with your doctor if it would be advisable for you to take enzyme supplements. Please dont hesistate to write to us if you need any more information or have additional quesitons.

      Reply
  • Loreen Yenglin
    Posted on April 15, 2020 at 8:49 pm

    Thanks for this inspirational and very well written article.

    Reply
    • PF NOW
      Posted on October 2, 2020 at 9:58 pm

      Thank you for your encouraging words!

      Reply
  • joanna Bennett
    Posted on May 21, 2020 at 12:11 am

    I live in the UK, would i be eligible to participate in your study

    Reply
    • PF NOW
      Posted on May 22, 2020 at 6:25 pm

      Hi Joanna, Yes, if you meet the other criteria, you would be eligible. Please look out for an email from us with some study details. Thank you for reaching out to us.

      Reply
  • jacob
    Posted on May 27, 2020 at 6:28 am

    Hello, I had two laplaparotomy surgeries due to small bowel obstruction in 2017 and 2018. Since then, internal scar tissues have been bothering me.

    Recently, I feel I had inflammation in my belly. I feel tightness and mild pain inside my belly after meal. I am afraid to to have another surgery. Currently I am taking Serrapeptase 120,000 SPU twice a day. Should I increase the dosage? I am not sure if it will have a burden on my liver if I use a high dosage. Should I take nattokinase as well? Thanks

    Reply
    • PF NOW
      Posted on October 2, 2020 at 10:01 pm

      Hello Jacob, sorry we missed responding to you earlier. How do you feel currently? Hope you are doing better. Serrapeptase and Nattokinase have been shown to have synergistic effects in reducing inflammation and fibrosis. I feel it could benefit you to take both.

      Reply
  • Eddie
    Posted on May 27, 2020 at 4:13 pm

    I am currently taking systemic enzymes for inflammation. Can I take Serrapeptase and Nattokinase at the same time I take the systemic enzymes?

    Reply
    • PF NOW
      Posted on May 28, 2020 at 5:54 pm

      Hello Eddie, you have not mentioned which systemic enzymes you are taking for inflammation and whether you are taking them with food or on an empty stomach. Serrapeptase and Nattokinase are also systemic enzymes which have shown to have anti-inflammatory and anti-fibrotic effects and need to be taken on an empty stomach. Please let me know if you need any further information or clarification.

      Reply
  • Valerie
    Posted on June 16, 2020 at 8:02 pm

    I struggle with a lot of inflammation from stress -I have ptsd- and I have been riding the high blood pressure line since my twenties -twenty years now- I also have a hemangioma on my liver, a lot of scar tissues on major muscle groups from past car accidents and a multitude of high impact trauma and blunt force traumas. I’m a bit of a mess and I know I have to do something or I am quickly headed down the long road of heart disease and all of its trappings. I have not been diagnosed with PF so far. I was wondering if you could help me on what is a good dosage for nattokinase and serrapeptase to be effective. Also, what adverse effects to watch for. I would be most grateful for any information or direction.

    Reply
    • PF NOW
      Posted on June 19, 2020 at 5:37 pm

      Hi Valerie, I am sorry for what you going through and hope you find a combination that works for you. If this is your first time on systemic enzymes I advise you to start off slow so your body can become accustomed to the product. Possible adverse effects to look for is an upset stomach and possible nausea but know this only happens for a very select few and usually goes away after a few days. If you are allergic to Pineapple or Papaya there are ingredients within Serracor-NK (this is a supplement that contains both serrapeptase and nattokinase) that are from these sources. If you are on any type of blood thinning medication please do not take Serracor-NK.

      Please look out for an email from us with more details on dosage.

      Reply
  • Noajă Ion
    Posted on June 21, 2020 at 1:53 pm

    Eu sunt din România, as putea participa si eu la acest experiment? Vă mulțumesc!

    Reply
    • PF NOW
      Posted on June 23, 2020 at 5:20 pm

      Hello, this research study involves filling out questionnaires at different time points through out the study. The questionnaires are in English and for this particular study, we are limiting participation to people who are able to understand and complete them since we have no provision to translate them in Romanian or other languages. I’m sorry about that but please reach out if you’d like more information regarding breathing techniques or other natural ways that can help improve your quality of life.

      Reply
  • Jerry
    Posted on June 23, 2020 at 6:04 pm

    Can dogs benefit from taking? I have 3 about 75 pounds.

    Reply
    • PF NOW
      Posted on August 12, 2020 at 12:29 am

      Hi Jerry, I have heard of people using systemic enzyme supplements for their pets. We, however, do not specialize in animal science/medicine so are unable to make a recommendation to you. Thank you for reaching out to us.

      Reply
  • Allan D. Singh
    Posted on June 27, 2020 at 2:36 am

    Hi, I was diagnosed in 2006 with Stage IV COPD. No biopsy was ever done and I was never a smoker. A number of doctors have indicated that I do not show the classic signs of COPD. My Oxygen saturation level is 97%. I know I have some sort of lung disease because at times i go into coughing fits and it is difficult at times to get rid of the smallest amount of mucus. It is a weird cough. someone told me that is trapped air because the lung is damaged and it is difficult to get the air out. I am still on Symbicort and Spiriva and ocassionally I have to go on antibiotics. Can you send me the Serrapeptase and Nattokinase so that I can be part of your study group.

    Reply
    • PF NOW
      Posted on July 31, 2020 at 6:34 pm

      Hello Allan, thank you for reaching out to us. I’m sorry to hear about your lung condition and your symptoms. Our current research study is specifically for people with a diagnosis of pulmonary fibrosis and not COPD so you would not qualify for our study. If you would like to purchase these enzymes and need help with dosage etc., please feel free to reach out to us and we can help you. Serrapeptase has been shown to help with thinning and drainage of mucus, hence it may benefit you. I would also recommend breathing exercises for you to improve your breathing and help strengthen your respiratory muscles. You can find some exercises on the following links: https://pulmonaryfibrosisnow.org/learn/exercise-your-lungs-2/#excercise and https://pulmonaryfibrosisnow.org/2020/03/10/balloon-breathing-exercise-for-improved-lung-function/
      Please let us know if you need any other information.

      Reply
  • Mindy Moore
    Posted on July 5, 2020 at 7:47 pm

    Greetings and many thanks in advance for your valuable time and help.

    I am trying to understand if the Nattokinase/Serrapeptase Supplement my doctor ordered to help dissolve a blood clot in my leg could possibly impact my cancer (Ductal Carcinoma In Situ). This type of breast cancer is characterized by cancerous cells which are still contained within the milk ducts.

    My question is whether Nattokinase or Serrapeptase could act as a catalyst in degrading the extracellular matrix and basement membranes which might create a pathway whereby my cancerous cells could escape the duct and spread to surrounding tissue and beyond.

    It has been very difficult for me to find and answer for this and I would be very appreciative if you could help me understand.

    Very respectfully yours, Mindy

    Reply
    • PF NOW
      Posted on July 7, 2020 at 10:36 pm

      Hi Mindy, thank you for reaching out to us. I am sorry for everything you are going through. Have you decided what treatment you will undergo for the DCIS? I hope my response helps clarify your dilemma somewhat.
      Nattokinase is mostly associated with its fibrinolytic or fibrin dissolving action. It is also possibly effective in reducing blood pressure. Most research on Serrapeptase points to it’s anti-inflammatory, anti-edemic (swelling reducing) and mucolytic (break down or thinning of mucous) effects. It is believed to act on avital tissue (injured, dead and excess fibrin coating) and have no ill effects on normal living cells. Additionally, I did not come across any research suggesting these enzymes effect the breakdown or rearrangement of extracellular matrix proteins.
      I hope this helps and that along with your doctor’s advice, you come up with a treatment plan that is best suited for you. Please let me know if you have any more questions.

      Reply
  • Rick Bass
    Posted on July 8, 2020 at 4:13 am

    Hi. My boss have ocular pemphigoid. Do you think serrapeptase would wotk on him?

    Reply
    • PF NOW
      Posted on July 10, 2020 at 6:00 pm

      Hi Rick, thank you for reaching out to us. I have not seen any research done on effects of serrapeptase on ocular pemphigoid in particular, but there is much anecdotal evidence on the beneficial effects of serrapeptase on various autoimmune conditions. Serrapeptase also has anti-inflammatory effects which would help in an autoimmune condition. I feel it may be worthwhile for him to try serrapeptase supplements to see how they work for him and whether he feels any relief.

      Reply
  • Roger
    Posted on July 10, 2020 at 11:18 pm

    First, I want to say this is a very informative site! I have been interested in serrapeptase for some time. I had pneumonia a number of times over the years. My doctor tells me I have significant scarring in my lungs. After doing a fair amount of reading, I have seen it mentioned in a few places that a possible side effect of serrapeptase is pneumonitis. It has made me a bit nervous with regard to taking serrapeptase since the very enzyme that could help me could cause more difficulty breathing. I have searched and searched to see if this could be prevented while taking serrapeptase but haven’t found anything at all addressing this concern. I do also have slightly higher BP and sounds that adding nattokinase could be beneficial. Not sure if the above could qualify for your study and, if not, I understand. If it doesn’t help me qualify I would be very appreciative of information about avoiding pneumonitis while taking serrapeptase. Thank you in advance for any time or information.

    Reply
    • PF NOW
      Posted on July 21, 2020 at 11:31 pm

      Thank you Roger, we appreciate your positive feedback. There are a couple of isolated cases of pneumonitis reported that were associated with serrapeptase intake. However, during our research and interaction with the pulmonary fibrosis community, we have not come across this side effect. There are however, several reports on the antiinflammatory and mucus thinning effects of Serrapeptase as well as effects on pain reduction. And you are right, the nattokinase may also be beneficial in lowering your BP. Please let me know if you have a diagnosis of pulmonary fibrosis and we can then discuss study details. Please feel free to reach out to us with any other questions.

      Reply
  • Cindy
    Posted on July 30, 2020 at 8:04 am

    I’ve recently been diagnosed by X-ray with “COPD, emphysema type”, and am hoping I could be considered to be part of your study. As a non-smoker and health conscious person, the diagnosis has been very disheartening. I was exposed to fiberglass dust for 15 months at a job I had in my 20’s, but I tried to protect myself with a respirator mask. Do you think serrapeptase could help with whatever damage may have been caused by the fiberglass?

    Reply
    • PF NOW
      Posted on July 31, 2020 at 9:12 pm

      Hello Cindy, I am so sorry for everything you are going through. It is disheartening to get such a diagnosis, more so if you have been health conscious and tried to do what’s best for yourself. Unfortunately, our current study is for patients who have a diagnosis of pulmonary fibrosis, so you would not qualify. However, Serrapeptase has been shown to breakdown fibrosis and scar tissue and help with thinning and drainage of mucous and may be beneficial for your condition. If you need help with dosage etc., please reach out to us via email (fight@pulmonaryfibrosisnow.org) and I’d be happy to help you.

      Reply
  • Janjan
    Posted on July 30, 2020 at 9:48 am

    Hi, I have excessive scar tissue in one of my breast hence why I would like to try serrapeptase. I have ordered some at 80000iu strength, can u please advise how much I can take daily? I see some strengths are measured in SPU which is confusing me. Please can you advise

    Reply
    • PF NOW
      Posted on July 31, 2020 at 9:00 pm

      Hello, thank you for reaching out to us. Serrapeptase can help with scar tissue but it may take some time. We have anecdotal evidence that Serrapeptase 80K 6 capsules a day is good for breaking down scar tissue. Not sure on how many capsules you are currently taking but the goal is to reach 6. So 2 capsules 3 times and day or 3 capsules in the morning and 3 at night. But of course if you are currently taking less than that, you should slowly work your way up. As for SPU (serrapeptase units) and IU (international units), both are measurement units of enzyme activity but both are not equivalent to each other and different manufacturers measure it differently. IU is a general unit of measuring a wide range of enzymes while SPU is specifically for Serrapeptase. Hope this answers your questions. It is also important for you to remember to take these supplements on an empty stomach. Please let us know if you have further questions.

      Reply
  • Ela
    Posted on August 9, 2020 at 7:16 am

    What if my fibrinogen level îs 1.1? It means my boold îs too thin so serrapeptase îs not a food idea?! Nor îs nattokinase?!

    Reply
    • PF NOW
      Posted on August 11, 2020 at 8:51 pm

      Hello Ela, thank you for reaching out to us. As you may know, the normal fibrinogen range is 2-4 g/L. There could be several reasons for your low fibrinogen level and your doctor may order additional tests to determine that. Fibrinogen levels are an indicator of clotting ability and low fibrinogen levels reduce your body’s ability to form a stable blood clot. From my research and experience, it would not be a good idea for you to take serrapeptase or nattokinase given your low fibrinogen level, as these enzymes can increase your risk for bleeding. Hope you are able to receive a proper diagnosis and find a resolution to your condition. Please write to us if you have additional questions.

      Reply
  • Laragh
    Posted on August 10, 2020 at 1:50 am

    I have severe aortic valve stenosis (high calcium score on CT) with occasional hypotension and high Lp(a). How much Nattokinase should I take and should I also take serrapeptase? BTW I am giving my dog serrapeptase for bronchial fibrosis. Should I also give the dog Nattokinase? Many thanks.

    Reply
    • PF NOW
      Posted on August 14, 2020 at 8:07 pm

      Hello, thank you for reaching out to us. We are not able to make recommendations for specific conditions. Serrapeptase and Nattokinase are natural supplements that support various functions in the body and may help your condition. The enzymes taken together are thought to have synergistic effects and it may be beneficial to you to add serrapeptase to your regimen. We have heard of people using systemic enzyme supplements for their pets. We, however, do not specialize in animal science/medicine so are unable to make a recommendation to you regarding your dog. Thank you for reaching out to us. You can also email us at fight@pulmonaryfibrosisnow.org

      Reply
  • mary lanahanwright
    Posted on August 11, 2020 at 9:30 pm

    i had covid 19 in may of this year and have free iron in my lungs now from a cytokine storm. i have noticed that i am short of breath quite often. also i have a-fib and cant seem to tolerate blood thinners since covid and the doctors trying to get me on blood thinners my blood pressure has shot up so i stopped the blood thinner and its a little better but still elevated.what would work for me?

    Reply
    • PF NOW
      Posted on August 12, 2020 at 12:25 am

      Hello Mary, thank you for reaching out to us. There is research pointing to the beneficial effects of Nattokinase on blood pressure. Serrapeptase and Nattokinase are both fibrinolytic enzymes and may help with lung fibrosis that may have occurred as a result of the cytokine storm during your covid infection. We are currently conducting a research study looking at the effects of serrapeptase and nattokinase on symptoms including shortness of breath in people with pulmonary fibrosis. Both these enzymes are also thought to have blood thinning effects and may be a natural alternative to prescription blood thinners. Please consult with your doctor to see if these supplements are right for you. If you’d like, I can email you dosage recommendations. Hope this helps and you are able to find the right combination to help support and improve your health. Please let me know if you have any more questions

      Reply
  • Simon Gordon-Smith
    Posted on August 13, 2020 at 2:28 pm

    My husband and I live in the Czech Republic. 3 years ago he has been diagnosed with Chronic Pulmonary Fibrosis / sometimes called “farmers lung”. He is taking Cortisones and we are looking for an alternative way. Would like to be a part of the research group

    Reply
    • PF NOW
      Posted on August 14, 2020 at 7:47 pm

      Hello, thank you for reaching out to us. I’m sorry to hear about your husband’s diagnosis. There are natural and alternatives ways of improving symptoms and quality of life that your husband can try. Unfortunately at this time, the postal service is really backed up and we are unsure if the Czech republic is accepting packaging so it would be difficult to enroll him on our research study. However, if you are able to buy serrapeptase and nattokinase supplements locally, I would encourage your husband to try them as we believe it would benefit him. Meanwhile, I would also recommend breathing exercises to help improve breathing. Please see the following link for breathing techniques: https://www.pulmonaryfibrosisnow.org/learn/exercise-your-lungs#excercise. For more information, please write to us at fight@pulmonaryfibrosisnow.org

      Reply
  • Avril Harper
    Posted on August 22, 2020 at 1:06 am

    Hello I have been diagnosed with IPLF approx 4 years ago. I have been taking NAC and Serrapeptase for about 3 years. I take them just once a day. I have recently bought some Nattokinase. If it alight to take the three together and can you please tell me how many per day.
    I would love to hear from you. Avril x

    Reply
    • PF NOW
      Posted on August 25, 2020 at 9:53 pm

      Hello Avril, thank you for reaching out to us. We do recommend taking Serrapeptase and Nattokinase together as they are thought to have beneficial synergistic effects. Without knowing the strength of the supplements you have, I would be unable to tell you how many you need to take per day. You can email us at fight@pulmonaryfibrosisnow.org with the specifics, and we will be able to guide you.

      Reply
  • Bhuvnesh Thakar
    Posted on August 25, 2020 at 11:12 am

    My wife and I live in Ahmedabad, INDIA. My wife has pulmonary fibrosis since 2014. She is now on 24 hours oxygen. will it help taking these enzymes? Would like to start immediately. Can arrange to get these from US with some one coming to India. LEt me know how much it can help. We are also ready to participate in the research study on the same.

    Reply
    • PF NOW
      Posted on August 25, 2020 at 9:45 pm

      Hello, thank you for reaching out to us. Sorry to hear about your wife’s condition. We have some evidence to show that these enzyme supplements help with symptoms and have even been reported to reduce supplemental oxygen requirements. I think it may be worthwhile for your wife to try these supplements and see if they work for her. Please look out for an email from us with more details.

      Reply
  • JJ
    Posted on September 4, 2020 at 4:33 pm

    Both nattokinase and Serrapeptase are great… have you looked into Lumbrokinase as well?

    I wonder if the combo of the above, with fish oil, is a reasonable substitution for the dangerous anticoagulants Eliquis and Warfarin? I was found to have a DVT in my lower rt leg a few days ago and am trying to decide on a course of treatment.
    Thanks!

    Reply
    • PF NOW
      Posted on September 8, 2020 at 6:35 pm

      Hello JJ, thank you for reaching out to us. Lumbrokinase is thought to be an antithrombotic agent, meaning it helps prevent clots. There is little scientific evidence to support this, but it has been used in traditional Chinese medicine to treat various conditions including circulatory and respiratory disorders. We are currently conducting research on serrapeptase and nattokinase as we have some scientific as well as a lot of anecdotal evidence on their benefits in people with pulmonary fibrosis. Since these enzymes are thought to have fibrinolytic and anticoagulant effects, I think it is reasonable to expect that, along with fish oil, they may be effective for your condition. However, there is a chance that DVT can result in pulmonary embolism which is life threatening. Blood thinners like heparin that are administered via injection provide an immediate anticoagulation effect and may be necessary initially. For long term use if you’d like natural alternatives, you can talk to your doctor about using these enzyme supplements in place of prescription anticoagulants.

      Reply
  • Julia
    Posted on October 13, 2020 at 12:36 am

    Hello, I have CKD from glomerulonephritis cased from systemic lupus. My lupus is in remission, however my GFR is 25.I’ve been told that I now have a large amount of scar tissue causing high protein in my urine. Could this help with my kidneys? If you think it might help, can you recommend a dose?

    Thank you,
    Julia

    Reply
    • PF NOW
      Posted on October 13, 2020 at 10:01 pm

      Hi Julia, thank you for reaching out to us. Serrapeptase and nattokinase are fibrin-digesting enzymes and can possibly help with scar tissue anywhere in your body. Please look out for an email from us regarding recommended dosages.

      Reply

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